Isolation of novel sequences targeting highly variable viral protein hemagglutinin
نویسندگان
چکیده
منابع مشابه
Isolation of novel sequences targeting highly variable viral protein hemagglutinin☆
Rapid evolution is a hallmark of the viral kingdom and a major concern for developing universal vaccines. The isolation of substantial numbers of viral sequence variants at highly variable viral protein domains remains a major challenge. We previously developed a combinatorial method for the isolation of novel sequences to cope with rapid viral variations at the G-H loop of Foot and Mouth Disea...
متن کاملIsolation of Recombinant Phage Antibodies Targeting the Hemagglutinin Cleavage Site of Highly Pathogenic Avian Influenza Virus
Highly pathogenic avian influenza (HPAI) H5N1 viruses, which have emerged in poultry and other wildlife worldwide, contain a characteristic multi-basic cleavage site (CS) in the hemagglutinin protein (HA). Because this arginine-rich CS is unique among influenza virus subtypes, antibodies against this site have the potential to specifically diagnose pathogenic H5N1. By immunizing mice with the C...
متن کاملNovel organelle-targeting signals in viral proteins
INTRODUCTION Peroxisomes are vital cellular organelles controlling important metabolic functions like hydrogen peroxide degradation, fatty acid metabolism, gluconeogenesis, toxin degradation, etc. (Flatmark et al., 1988; van den Bosch et al., 1992; Masters, 1997; Lopez-Huertas et al., 2000). Certain human metabolic disorders such as Zellweger syndrome, neonatal adrenoleukodystrophy, infantile R...
متن کاملIsolation and expression of recombinant viral protein (VP2) from Iranian isolates of Infectious Pancreatic Necrosis Virus (IPNV) in Escherichia coli
Infectious Pancreatic Necrosis Virus (IPNV) is a member of the family Birnaviridae that has been linked to high mortalities in salmonids. Bacterial based systems as live vectors for the delivery of heterologous antigens offer a number of advantages as vaccination strategies. VP2 is a structural viral protein of IPNV with immunogenicity effects. In this study IPNV was isolated from diseased fry ...
متن کاملMalware Detection using Classification of Variable-Length Sequences
In this paper, a novel method based on the graph is proposed to classify the sequence of variable length as feature extraction. The proposed method overcomes the problems of the traditional graph with variable length of data, without fixing length of sequences, by determining the most frequent instructions and insertion the rest of instructions on the set of “other”, save speed and memory. Acco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: MethodsX
سال: 2015
ISSN: 2215-0161
DOI: 10.1016/j.mex.2015.02.005